The tour begins on Spaccanapoli, the long straight street that cuts directly through the historic center and remains one of the most vivid expressions of Neapolitan street culture. Local commerce, religious shrines, and centuries-old architecture create a layered backdrop for this opening segment of the walk.

The route passes through San Gregorio Armeno, one of the most distinctive streets in Naples, where family-run workshops produce handcrafted nativity scene figures using techniques passed down through generations. The tradition of the Neapolitan presepe is recognized as one of the region's most significant cultural expressions.

The walk continues along Via dei Tribunali, which follows the original east-west axis of ancient Neapolis. The street is flanked by historic churches, Renaissance courtyards, and active neighborhood scenes that have changed little in their essential character over centuries.

The tour arrives at the Duomo di Napoli on Via Duomo, the city's principal Gothic cathedral, which incorporates architectural elements spanning from antiquity to the medieval period. The exterior and interior both reward close attention, offering a condensed history of Naples' religious and civic identity.

The final stop is the Chapel of San Gennaro, located within the cathedral, which houses the preserved blood of the city's patron saint along with an extraordinary collection of jewels, silver objects, and sacred items donated by Neapolitans as acts of devotion over more than four centuries. The chapel represents one of the most significant expressions of popular religious culture in southern Italy.